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FitzGerald, JE,Grenon, M,Lowndes, NF
53BP1: function and mechanisms of focal recruitment
BIOCHEMICAL SOCIETY TRANSACTIONS
2009
August
Published
1
()
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Dot1 histone 2AX (H2AX) histone methylation mediator of DNA-damage checkpoint 1 (MDC1) p53-binding protein 1 (53BP1) Rad9 DNA-DAMAGE-RESPONSE DOUBLE-STRAND BREAKS PROTEIN 53BP1 HISTONE H2AX GENOMIC INSTABILITY CELLULAR-RESPONSE H3 METHYLATION BRCT DOMAINS YEAST RAD9 CHECKPOINT
897
904
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
DOI 10.1042/BST0370897
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