Other Publication Details
Mandatory Fields
Reviews
Kulkarni, M,Greiser, U,O'Brien, T,Pandit, A
2010
January
Liposomal gene delivery mediated by tissue-engineered scaffolds
Published
1
Optional Fields
CELLS IN-VITRO CATIONIC LIPOSOMES NONVIRAL VECTORS DNA DELIVERY PHARMACEUTICAL NANOCARRIERS CONTROLLED-RELEASE NEURITE EXTENSION FUSOGENIC PEPTIDE ENDOSOMAL ESCAPE SIRNA DELIVERY
In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome-scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.
28
36
DOI 10.1016/j.tibtech.2009.10.003
Grant Details
Publication Themes