Conference Publication Details
Mandatory Fields
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L
Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS
2009
September
Published
1
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Optional Fields
cancer apoptosis TRAIL resistance NF-kappa B proteasome inhibitors super repressor mTOR TRAIL-INDUCED APOPTOSIS CANCER-CELL-LINES FADD-DEPENDENT APOPTOSIS X-LINKED INHIBITOR MEDIATED APOPTOSIS CARCINOMA CELLS TNF-ALPHA GLIOBLASTOMA-MULTIFORME PROTEASOME INHIBITORS MULTIPLE-MYELOMA
38
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One strategy for cancer management consists of promoting selective apoptosis of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a proapoptotic cytokine, is a promising anticancer agent because of its ability to selectively induce apoptosis in established tumor cell lines but not in nontransformed cells. However, many tumors have developed mechanisms of resistance against killing by TRAIL. Whether or not the transcription factor nuclear factor (kappa B) is involved in TRAIL resistance is uncertain, and this short review aims to summarize currently available data on this question.
DOI 10.1111/j.1749-6632.2009.04725.x
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