Other Publication Details
Mandatory Fields
Reviews
Fitzgerald, KT,Holladay, CA,McCarthy, C,Power, KA,Pandit, A,Gallagher, WM
2011
March
Standardization of Models and Methods Used to Assess Nanoparticles in Cardiovascular Applications
Published
1
Optional Fields
SUPERPARAMAGNETIC IRON-OXIDE INDUCED HYPERSENSITIVITY REACTIONS APOLIPOPROTEIN-E-DEFICIENT LIPID-BASED NANOPARTICLES CELL-ADHESION MOLECULE-1 FIBROBLAST-GROWTH-FACTOR ADULT STEM-CELLS MAGNETIC-RESONANCE IN-VIVO ATHEROSCLEROTIC PLAQUES
Nanotechnology has the potential to revolutionize the management and treatment of cardiovascular disease. Controlled drug delivery and nanoparticle-based molecular imaging agents have advanced cardiovascular disease therapy and diagnosis. However, the delivery vehicles (dendrimers, nanocrystals, nanotubes, nanoparticles, nanoshells, etc.), as well as the model systems that are used to mimic human cardiac disease, should be questioned in relation to their suitability. This review focuses on the variations of the biological assays and preclinical models that are currently being used to study the biocompatibility and suitability of nanomaterials in cardiovascular applications. There is a need to standardize appropriate models and methods that will promote the development of novel nanomaterial-based cardiovascular therapies.
705
717
DOI 10.1002/smll.201001347
Grant Details
Publication Themes