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Howley, B,Fearnhead, HO
2008
September
Caspases as therapeutic targets
Published
1
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apoptosis inhibitors inflammation transplant INTERLEUKIN-1-BETA CONVERTING-ENZYME NF-KAPPA-B FAMILIAL MEDITERRANEAN FEVER ISCHEMIA-REPERFUSION INJURY LIVER PRESERVATION INJURY DOMAIN-CONTAINING PROTEIN ALZHEIMERS-DISEASE BRAIN PROGRAMMED CELL-DEATH GAMMA-INDUCING FACTOR MUTANT HUNTINGTIN
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
1502
1516
DOI 10.1111/j.1582-4934.2008.00292.x
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