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Costelloe, T,FitzGerald, J,Murphy, NJ,Flaus, A,Lowndes, NF
2006
August
Chromatin modulation and the DNA damage response
Published
1
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DNA chromatin DNA damage response histone DOUBLE-STRAND BREAKS HISTONE ACETYLTRANSFERASE ACTIVITY NUCLEOSOME CORE PARTICLE REMODELING COMPLEX SACCHAROMYCES-CEREVISIAE H2A PHOSPHORYLATION CHECKPOINT ACTIVATION ANGSTROM RESOLUTION REPAIR PROTEINS H3 METHYLATION
The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.
2677
2686
DOI 10.1016/j.yexcr.2006.06.031
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