Peer-Reviewed Journal Details
Mandatory Fields
Fleming, SM,O'Byrne, L,Grimes, H,Daly, KM,Morrison, JJ
2001
January
Hypertens Pregnancy
Amino-terminal pro-brain natriuretic peptide in normal and hypertensive pregnancy
Published
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Optional Fields
brain natriuretic peptide hypertension in pregnancy multigravidity MATERNAL HEMODYNAMICS MYOCARDIAL-INFARCTION HEART-FAILURE PREECLAMPSIA DYSFUNCTION PRESSURE
20
169
175
Objectives: To investigate serum levels of amino-terminal pro-brain natriuretic peptide (Nt pro-BNP) as an index of left-ventricular function in normal pregnancy and pregnancies complicated by hypertension and also to investigate levels in both primigravid and multigravid women.Methods: Women with hypertension in pregnancy (at least two readings of systolic blood pressure > 140 mm Hg and diastolic blood pressure > 90 mm Hg) (n=24) and normotensive women (n=42) were included in the study. Serum Nt pro-BNP was measured using an enzyme-linked immunosorbent assay technique.Results: The median serum Nt pro-BNP level in pregnancies complicated by hypertension was 420 fmol/L, which was significantly greater than that measured in samples obtained from normotensive women in pregnancy (340 fmol/L) (p=0.03). There was a nonsignificant trend toward increased levels in proteinuric as compared to nonproteinuric hypertension in pregnancy. Multigravida had higher Nt pro-BNP levels (n=26; median Nt pro-BNP=358 fmol/L) than primigravida (n=16; median Nt pro-BNP=278 fmol/L) (p=0.01) in association with normal pregnancy. Multigravida also demonstrated a dramatic rise in serum Nt pro-BNP levels in association with hypertension in pregnancy (n=13; median Nt pro-BNP=572 fmol/L) as compared to normal pregnancy (n=26; median Nt pro-BNP=358 fmol/L) (p=0.009).Conclusion: Serum Nt pro-BNP is elevated in women with hypertensive disorders of pregnancy, indicating elevated left-ventricular filling pressures. Measured serum levels in both normal and hypertensive pregnancy are higher in multigravida than in primigravida.
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