Peer-Reviewed Journal Details
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Bourke, MG,Martin, ST,O'Dwyer, M,Hanaghan, J,Bennani, F,Barry, MK
Irish Journal Of Medical Science
Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder
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JAK2 V617F Mesenteric infarction Mesenteric venous thrombosis Myeloproliferative disorders Janus kinase Tyrosine kinase Erythropoeitin receptor MUTATION PREVALENCE V617F
Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs.We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.
DOI 10.1007/s11845-009-0331-7
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