Peer-Reviewed Journal Details
Mandatory Fields
O'Neill CP;Dwyer RM;
2020
February
Cells
Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy.
Published
Optional Fields
9
2
Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.
2073-4409
10.3390/cells9020521
Grant Details
Publication Themes