Conference Publication Details
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Burke, AJ; O'Connell, E; Miranda, KM; Giles, FJ; Sullivan, F; Glynn, SA
Royal Academy of Medicine in Ireland Annual Meeting
Nitric Oxide and its effects on cellular proliferation and phenotype in prostate cancer
2012
June
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NUI Galway, Ireland
Nitric Oxide (NO) is a free radical produced by upregulation of inducible nitric oxide synthase during chronic inflammation. Nitroxyl (HNO) is the reduced form of NO which possesses distinct biological properties separate to NO. The mechanism of HNO synthesis remains unclear but it is known to be a downstream intermediary of NO. We hypothesize that chronic inflammation is instrumental in prostate cancer development and that NO plays a role in the transformation of normal cells. Nitric oxide (NO) regulates multiple physiological functions including cell proliferation. The regulatory action of NO on cell proliferation is exerted in a bimodal fashion, both enhancing and inhibiting the progression of the proliferative process depending on the concentration of NO encountered by the cell. In this study, HNO (IPA/NO) and NO (DEA/NO) donors in the form of novel drugs individually and chemically coupled with acetylsalicylic acid (aspirin), are investigated as potential modulators of prostate cancer cell proliferation. 
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