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Jarrin, S;Finn, DP
2019
October
Optogenetics and its application in pain and anxiety research
Published
1
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ANTERIOR CINGULATE CORTEX CENTRAL AMYGDALA UNITED-STATES FORMALIN TEST AFFECTIVE COMPONENT INFLAMMATORY PAIN OPIOID RECEPTORS ANIMAL-MODELS ACTIVATION NEURONS
Chronic pain and anxiety can be debilitating disorders and are often comorbid. There is significant overlap in the neural circuitry of pain and anxiety. Current treatments for these disorders are often ineffective and have negative side-effects, making further research into pain and anxiety circuitry crucial. The technique of optogenetics is propelling the possibilities for functional neuroanatomical research. With the use of light-activated proteins called opsins, optogenetics enables the switching on or off of a selective population of neurons, with precise temporal control. This manuscript reviews recent research that has employed optogenetic methodology to advance understanding of the neural circuitry of pain and anxiety and identify novel approaches for their improved treatment.
OXFORD
PERGAMON-ELSEVIER SCIENCE LTD
0149-7634
200
211
10.1016/j.neubiorev.2019.08.007
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