Welded joints in tempered 9Cr-1Mo operating at elevated temperatures are well known to be prone to premature failure due to cracking in the heat-affected zone. This paper describes a crystal plasticity model to predict the microcrack initiation and evolution in the inter-critical heat-affected zone of 9Cr-1Mo welded steel at elevated temperature. A crystal plasticity finite element model indicates that the micro-cracks of 9Cr-1Mo steel mostly nucleate at prior austenite grain boundaries and boundary clustered regions. Inter-granular and trans-granular microcracking are shown to be the key predicted microdamage mechanisms from the current crystal plasticity model. A small amount of ferrite in the inter-critical heat-affected zone is shown to not only influence the microcrack initiation and evolution, but also significantly accentuate material degradation for a given applied load leading to premature failure at high temperature.