Peer-Reviewed Journal Details
Mandatory Fields
Mulcahy, C;Mone, F;McParland, P;Breathnach, F;Cody, F;Morrison, JJ;Higgins, J;Daly, S;Dornan, S;Cotter, A;Dicker, P;Tully, E;Malone, FD;McAuliffe, FM
2019
July
American Journal Of Perinatology
The Impact of Aspirin on Ultrasound Markers of Uteroplacental Flow in Low-Risk Pregnancy: Secondary Analysis of a Multicenter RCT
Published
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Optional Fields
UTERINE ARTERY DOPPLER FETAL-GROWTH RESTRICTION LOW-DOSE ASPIRIN PLACENTAL VASCULAR SONOBIOPSY BLOOD-FLOW PREECLAMPTIC PLACENTAS REFERENCE RANGES VOLUME 1ST PREVENTION
36
855
863
Objective This article evaluates the effect of low-dose aspirin on uterine artery (UtA) Doppler, placental volume, and vascularization flow indices in low-risk pregnancy.Study Design In this secondary analysis of the TEST randomized controlled trial, low-risk nulliparous women were originally randomized at 11 weeks to: (1) routine aspirin 75mg; (2) no aspirin; and (3) aspirin based upon the preeclampsia Fetal Medicine Foundation screening test. UtA Doppler, three-dimensional (3D) placental volume, and vascularization flow indices were assessed prior to and 6 weeks postaspirin commencement.Results A total of 546 women were included (aspirin n =192, no aspirin n =354). Between first and second trimesters, aspirin use was not associated with a change in UtA Doppler, placental volume, or vascular flow indices. There was no significant difference in the change in UtA Doppler pulsatility index (PI) Z -scores or notching (PI Z -score -0.2 vs. -0.2, p =0.17), nor was there a significant change in placental volume Z -score and vascular flow indices (volume Z -score change: 0.74 vs. 0.62, p =0.34).Conclusion Low-dose aspirin commenced at 11 weeks in low-risk women does not appear to improve uterine and placental perfusion or placental volume. Any perceived effect on uteroplacental vasculature is not reflected in changes in placental volume nor uteroplacental flow as assessed by two-dimensional and 3D ultrasound.
0735-1631
10.1055/s-0038-1675208
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