Concentrations of decabromodiphenyl ethane (DBDPE), 13 polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), were measured in indoor air and dust collected from Irish homes, cars, offices and primary schools during 2016-17. Median concentrations of DBDPE in air (88 pg/m3) and dust (6,500 ng/g) exceed significantly those previously reported internationally, with concentrations highest in offices and schools, suggesting DBDPE is widely used in Ireland. Median concentrations of BDE-209 in air (340 pg/m3) and dust (7,100 ng/g) exceed or are within the range of concentrations reported recently for the same microenvironments in the UK, and exceed those reported in many other countries. Concentrations of BDE-209 in cars exceeded significantly (p<0.05) those in other micro-environments. HBCDD was detected in all dust samples (median: 580 ng/g), and in 81% of air samples (median: 24 pg/m3) at concentrations similar to those reported recently for the UK and elsewhere. Estimates of exposure to DBDPE of Irish adults (92 ng/day) and toddlers (210 ng/day) as well as to BDE-209 (220 ng/day and 650 ng/day for adults and toddlers respectively) exceed substantially those reported for the UK population. Moreover, our estimates of exposure of the Irish population to ¿tri-deca-PBDEs exceed previous estimates for Ireland via dietary exposure.