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Paladino, NC;Guerin, C;Lowery, A;Attard, A;Essamet, W;Slotema, E;Morange, I;Castinetti, F;Brue, T;Loundou, A;Taieb, D;Sebag, F
2018
June
Surgical Oncology-Oxford
Characterization of adrenocortical tumors by F-18-FDG PET/CT: Does steroid hormone hypersecretion status modify the uptake pattern?
Published
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EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY ADRENAL MASSES FDG-PET/CT CANCER-PATIENTS ACCURACY LESIONS METASTASES DIAGNOSIS BENIGN SCORE
27
231
235
Background: adrenal tumor-to-liver uptake value (Tmx:Lmx) on F-18-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses. The potential impact of steroid hormone secretion on F-18-FDG uptake is still debatable. The aim of this study was to evaluate this relationship.Methods: 2010-2015: 73 patients who underwent adrenalectomy for adrenocortical tumors [49 secreting/(SA) and 24 non-secreting/(NSA)] were retrospectively included in the study. Fourteen were malignant. All patients underwent hormonal evaluation, functional and anatomical imaging, Weiss scoring and Ki 67 evaluation.Results: malignant tumors exhibit higher SUV-max than benign tumors (median 7.75 vs 3.06 respectively, p <0.001) and Tmx:Lmx was 2.7 vs 1.17 for benign tumors, p <0.001.Tmx:Lmx was positively correlated to Weiss score (p <0.001).No significant difference was observed for Tmx:Lmx between SA and NSA overall (p = 0.851), regardless of the subgroup of tumors analyzed. Tmx:Lmx was not correlated to tumor size (p <0.508) or 24 h free urinary cortisol level (p <0.522).Conclusions: no correlation was observed between Tmx:Lmx and hormonal status, however the correlation between ratio, malignancy and Weiss score confirm the utility of F-18-FDG PET/CT for the differentiation of benign from malignant adrenal lesions, irrespective of the hormone secretory status of the tumor. F-18-FDG PET/CT is a useful biomarker in the diagnosis of adrenal tumors, regardless of the secretion status. (C) 2018 Elsevier Ltd. All rights reserved.
0960-7404
10.1016/j.suronc.2018.04.003
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