Conference Publication Details
Mandatory Fields
Okine, BN;Gaspar, JC;Finn, DP
BRITISH JOURNAL OF PHARMACOLOGY
PPARs and pain
2019
May
Published
1
WOS: 3 ()
Optional Fields
ACTIVATED-RECEPTOR-ALPHA FATTY-ACID AMIDE AUGMENTED PERIPHERAL INFLAMMATION ATTENUATES TACTILE ALLODYNIA SPINAL-CORD-INJURY NEUROPATHIC PAIN RAT MODEL CONCISE GUIDE ANTIINFLAMMATORY ACTIVITIES PERIAQUEDUCTAL GREY
1421
1442
Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant adverse side effects. The PPARs, a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain. Modulation of nociceptive processing by PPARs is likely to involve both transcription-dependent and transcription-independent mechanisms. This review presents a comprehensive overview of preclinical studies investigating the contribution of PPAR signalling to nociceptive processing in animal models of inflammatory and neuropathic pain. We examine current evidence from anatomical, molecular and pharmacological studies demonstrating a role for PPARs in pain control. We also discuss the limited evidence available from relevant clinical studies and identify areas that warrant further research.
10.1111/bph.14339
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