Peer-Reviewed Journal Details
Mandatory Fields
Mc Cormack, O;Chung, WY;Fitzpatrick, P;Cooke, F;Flynn, B;Harrison, M;Fox, E;Gallagher, E;Mc Goldrick, A;Dervan, PA;Mc Cann, A;Kerin, MJ
2008
March
British Journal Of Cancer
Growth arrest-specific gene 6 expression in human breast cancer
Published
Altmetric: 2WOS: 32 ()
Optional Fields
TYROSINE KINASE RECEPTOR ARREST-SPECIFIC GENE-6 GAS6 RECEPTORS AXL RECEPTOR GROWTH IDENTIFICATION CELLS STABILIZATION COEXPRESSION ACTIVATION
98
1141
1146
Growth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ Tyro3 receptor family has been found in breast, ovarian and lung tumours. Gas6 is upregulated 23- fold by progesterone acting through the progesterone receptor B ( PRB). Recently, Gas6 has been shown to be a target for overexpression and amplification in breast cancer. Quantitative real- time PCR analysis was used to determine the levels of Gas6 mRNA expression in 49 primary breast carcinomas. Expression of PRB protein was evaluated immunohistochemically with a commercially available PRB antibody. The results showed a positive association between PRB protein and Gas6 mRNA levels ( P =0.04). Gas6 correlated positively with a number of favourable prognostic variables including lymph node negativity ( P =0.0002), younger age at diagnosis ( P =0.04), smaller size of tumours ( P =0.02), low Nottingham prognostic index scores ( P =0.03) and low nuclear morphology ( P =0.03). This study verifies for the first time the association between PRB and Gas6 in breast cancer tissue.
0007-0920
10.1038/sj.bjc.6604260
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