Peer-Reviewed Journal Details
Mandatory Fields
Plickert, G;Jacoby, V;Frank, U;Muller, WA;Mokady, O
2006
October
Developmental Biology
Wnt signaling in hydroid development: Formation of the primary body axis in embryogenesis and its subsequent patterning
Published
WOS: 56 ()
Optional Fields
ANIMAL-VEGETAL AXIS GLYCOGEN-SYNTHASE KINASE-3-BETA SEA-URCHIN EMBRYO HYDRACTINIA-ECHINATA BETA-CATENIN HEAD ORGANIZER METAMORPHOSIS EVOLUTION BRACHYURY CNIDARIAN
298
368
378
We have studied the role the canonical Writ pathway plays in hydroid pattern formation during embryonic development and metamorphosis. Transcripts of Wnt and Tcf were asymmetrically deposited in the oocyte and subsequent developmental stages, marking the sites of first cleavage, posterior larval pole and the upcoming head of the metamorphosed polyp. To address the function of these genes, we activated downstream events of the Writ pathway by pharmacologically blocking GSK-3 beta. These treatments rendered the polar expression of Tcf ubiquitous and induced development of ectopic axes that contained head structures. These results allow concluding that Writ signaling controls axis formation and regional tissue fates along it, determining one single axis terminus from which later the mouth and hypostome develop. Our data also indicate Writ functions in axis formation and axial patterning as in higher metazoans, and thus point to an ancestral role of Writ signaling in these processes in animal evolution. (c) 2006 Elsevier Inc. All rights reserved.
0012-1606
10.1016/j.ydbio.2006.06.043
Grant Details
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