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Li, J;Doyle, KM;Tatlisumak, T
2007
January
Polyamines in the brain: Distribution, biological interactions, and their potential therapeutic role in brain ischaemia
Published
1
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D-ASPARTATE RECEPTOR FOCAL CEREBRAL-ISCHEMIA ORNITHINE-DECARBOXYLASE ACTIVITY CULTURED CORTICAL-NEURONS EXCITATION IN-VIVO CELL-DEATH RAT-BRAIN BARRIER BREAKDOWN ARTERY OCCLUSION NMDA RECEPTOR
The endogenous polyamines (spermine, spermidine, and putrescine) are present at relatively high concentrations in the mammalian brain and play crucial roles in a variety of aspects of cell functioning. Stroke is the third most common cause of death and the leading cause of disability among adults in the western world. Brain polyamine levels change dramatically following cerebral ischaemia. Polyamines may be involved in the pathophysiological processes underlying brain ischaemia through several possible mechanisms. These include direct effects on ion channels and receptors modulating potassium, and most importantly calcium trafficking, or through the production of toxic metabolites. Considerable evidence shows that the noncompetitive polyamine antagonists, ifenprodil and cliprodil, are neuroprotective. Interestingly, novel polyamine analogues, such as N-1-dansylspermine, BU36b, and BU43b, have also recently been shown to have neuroprotective potential. The exact mechanisms of the neuroprotection afforded by the polyamine antagonists and their clinical applicability is worthy of further study.
SHARJAH
BENTHAM SCIENCE PUBL LTD
0929-8673
1807
1813
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