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Smith, KL;Jessop, DS;Finn, DP
2009
January
Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders
Published
1
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CORTICOTROPIN-RELEASING-FACTOR CLONIDINE-DISPLACING SUBSTANCE PITUITARY-ADRENAL AXIS ROSTRAL VENTROLATERAL MEDULLA LOCUS-COERULEUS NEURONS MONOAMINE-OXIDASE-A FORCED SWIM TEST PROTEIN-KINASE PHOSPHORYLATION IMIDAZOLEACETIC ACID-RIBOTIDE PC12 PHEOCHROMOCYTOMA CELLS
In this review, we present evidence for the involvement of imidazoline binding sites (IBS) in modulating responses to stress, through central control of monoaminergic and hypothalamo-pituitary-adrenal (HPA) axis activity. Pharmacological and physiological evidence is presented for differential effects of different IBS subtypes on serotoninergic and catecholaminergic pathways involved in control of basal and stress-stimulated HPA axis activity. IBS ligands can modulate behavioural and neuroendocrine responses in animal models of stress, depression and anxiety, and a body of evidence exists for alterations in central IBS expression in psychiatric patients, which can be normalised partially or fully by treatment with antidepressants. Dysfunction in monoaminergic systems and the HPA axis under basal and stress-induced activation has been extensively reported in psychiatric illnesses. On the basis of the literature, we suggest a potential therapeutic role for selective IBS ligands in the treatment of depression and anxiety disorders.
ABINGDON
TAYLOR & FRANCIS LTD
1025-3890
97
114
10.1080/10253890802302908
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