Peer-Reviewed Journal Details
Mandatory Fields
Grzywa, R;Sokol, AM;Sienczyk, M;Radziszewicz, M;Kosciolek, B;Carty, MP;Oleksyszyn, J
2010
April
Bioorganic And Medicinal Chemistry
New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
Published
WOS: 8 ()
Optional Fields
CARCINOMA CELLS ANGIOGENESIS
18
2930
2936
A series of new aromatic monoesters of alpha-aminoaralkylphosphonic acids were synthesized by selective hydrolysis of corresponding aromatic diesters of alpha-aminoaralkylphosphonic acids. New potential inhibitors of aminopeptidase N/CD13, an enzyme important in tumour angiogenesis, were developed. Some derivatives of the homophenylalanine and norleucine related monoaryl phosphonates displayed higher inhibition potency than corresponding alpha-aminoaralkylphosphonic acids toward aminopeptidase N/CD13. The effect of one of the new inhibitors on the growth of human PANC-1 and HT-1080 cell lines was examined, either alone or in combination with TNF-alpha. (C) 2010 Elsevier Ltd. All rights reserved.
0968-0896
10.1016/j.bmc.2010.02.056
Grant Details
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