Conference Publication Details
Mandatory Fields
Egan, LJ;Toruner, M
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS
NF-kappa B signaling - Pros and cons of altering NF-kappa B as a therapeutic approach
2006
January
Published
1
WOS: 37 ()
Optional Fields
INFLAMMATORY-BOWEL-DISEASE IKK-BETA T-CELLS EPITHELIAL-CELLS CROHNS-DISEASE ACTIVATION ALPHA INHIBITION PREVENTION EXPRESSION
114
122
The transcription factor, nuclear factor-kappa B (NF-kappa B), is a dominant regulator of the expression of hundreds of genes, many of which play important roles in the regulation of inflammation and programmed cell death (apoptosis). Since the discovery of NF-kappa B in the mid 1980s, this transcription factor has been the subject of intense investigation. Excess or inappropriate activation of NF-kappa B has been observed in human inflammatory bowel disease and in a host of other inflammatory diseases and type of cancer. Functional studies in animals have shed light on the role of NF-kappa B in broader pathophysiological contexts. From such studies, it has become quite clear that NF-kappa B plays unique and distinct functions in different cell types. Because of the importance of NF-kappa B in signaling inflammation, and in inhibiting programmed cell death, many pharmaceutical companies are developing small-molecule inhibitors of this pathway. In this article, we evaluate the relative pros and cons of blocking NF-kappa B as a therapeutic approach for inflammatory bowel disease. On the basis of the results of studies in animals that have primarily used genetic approaches to inhibit NF-kappa B activity, we suggest that there are certain niche indications for blocking NF-kappa B in inflammatory bowel disease that offer particular promise.
10.1196/annals.1326.009
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