Conference Publication Details
Mandatory Fields
McQuaid, S;Cunnea, P;McMahon, J;Fitzgerald, U
BIOCHEMICAL SOCIETY TRANSACTIONS
The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis
2009
February
Published
1
Altmetric: 2WOS: 35 ()
Optional Fields
APPEARING WHITE-MATTER CLINICAL-IMPLICATIONS ENHANCING LESIONS ABNORMALITIES OLIGODENDROCYTES FIBRONECTIN PATHOLOGY DISEASE MRI
329
331
Dysfunction of the BBB (blood-brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased 131313 permeability is associated with decreased expression of TJ (tight junction) proteins in brain capillary endothelial cells. Results have revealed that TJ abnormalities were most common in active lesions (42% of vessels affected), but were also present in inactive lesions (23%) and in MS normal-appearing white matter (13%). Importantly, TJ abnormality was also positively associated with leakage of the serum protein fibrinogen which has recently been shown to be an activator of microglia. TJ abnormality and the resultant vascular permeability in both lesional and non-lesional white matter may impair tissue homoeostasis, which may have effects on disease progression, repair mechanisms and drug delivery.
10.1042/BST0370329
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