Peer-Reviewed Journal Details
Mandatory Fields
Smith, RWP;Nasheuer, HP
2003
May
European Journal Of Biochemistry
Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase
Published
WOS: 7 ()
Optional Fields
HUMAN POLYOMAVIRUS-JC LARGE T-ANTIGEN PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY SPECIES-SPECIFIC REPLICATION FUNCTIONAL-CHARACTERIZATION REGULATORY REGION COMPLEX-FORMATION SV40 ORIGIN P48 CONTROL HOST-RANGE
270
2030
2037
Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase alpha-primase complex involved in the initiation of both viral and host DNA replication. Here we demonstrate that DNA replication of the related human pathogenic polyomavirus JC virus (JCV) can be supported in vitro by DNA polymerase alpha-primase of either human or murine origin indicating that the mechanism of its strict species specificity differs from that of SV40 and PyV. Our results indicate that this may be due to differences in the interaction of JCV and SV40 large T antigens with the DNA replication initiation complex.
0014-2956
10.1046/j.1432-1033.2003.03579.x
Grant Details
Publication Themes