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Reviews
Mancuso, P;Raman, S;Glynn, A;Barry, F;Murphy, JM
2019
January
Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome
Published
1
Optional Fields
STROMAL CELLS INTRAARTICULAR INJECTION T-CELLS JOINT DISEASE INDOLEAMINE 2,3-DIOXYGENASE MATRIX METALLOPROTEINASES MYOCARDIAL-INFARCTION CYTOKINE PRODUCTION INDUCED ARTHRITIS INTERFERON-GAMMA
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments. Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical models aiming to resurface the degenerated cartilage. In early-phase clinical trials, intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. However, the consistent lack of engraftment indicates that the observed effect is delivered through a "hit-and-run" mechanism, by a temporal release of paracrine molecules. MSCs express a variety of chemokines and cytokines that aid in repair of degraded tissue, restoration of normal tissue metabolism and, most importantly, counteracting inflammation. Secretion of therapeutic factors is increased upon licensing by inflammatory signals or apoptosis, induced by the host immune system. Trophic effectors are released as soluble molecules or carried by extracellular vesicles (ECVs). This review provides an overview of the functions and mechanisms of MSC-secreted molecules found to be upregulated in models of OA, whether using in vitro or in vivo models.
LAUSANNE
FRONTIERS MEDIA SA
2296-4185
10.3389/fbioe.2019.00009
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