Peer-Reviewed Journal Details
Mandatory Fields
Roche, M;Diamond, M;Kelly, JP;Finn, DP
2006
December
Journal Of Neuroimmunology
In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids
Published
WOS: 48 ()
Optional Fields
RAT MICROGLIAL CELLS CORTICOTROPIN-RELEASING-FACTOR MESSENGER-RNA EXPRESSION NITRIC-OXIDE PRODUCTION PITUITARY-ADRENAL AXIS NECROSIS-FACTOR-ALPHA RECEPTOR AGONIST ENDOCANNABINOID SYSTEM MULTIPLE-SCLEROSIS VANILLOID RECEPTORS
181
57
67
This study investigated cannabinoid receptor-mediated regulation of brain and peripheral cytokines in vivo. The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1 beta and TNF alpha in rat brain and IL-1 beta, TNF alpha, IL-6 and IFN gamma in plasma. The CB1 receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1 beta, but not TNF alpha. SR141716A or the CB2 receptor antagonist, SR144528, alone attenuated LPS-induced cytokine increases. LPS and/or cannabinoids also reduced circulating lymphocyte numbers and increased corticosterone levels. These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders. (c) 2006 Elsevier B.V. All rights reserved.
0165-5728
10.1016/j.jneuroim.2006.08.001
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