Peer-Reviewed Journal Details
Mandatory Fields
Nugent, C;Roche, K;Wilson, S;Fitzgibbon, M;Griffin, D;NiChaidhin, N;Mulkerrin, E
2010
March
Irish Journal of Medical Science
The effect of intramuscular vitamin D (cholecalciferol) on serum 25OH vitamin D levels in older female acute hospital admissions
Published
WOS: 9 ()
Optional Fields
RANDOMIZED CONTROLLED-TRIAL PLACEBO-CONTROLLED TRIAL D SUPPLEMENTATION PARATHYROID-HORMONE ELDERLY-WOMEN HIP FRACTURE DOUBLE-BLIND CALCIUM PREVENTION MEN
179
57
61
Introduction Many studies have demonstrated the prevalence of vitamin D insufficiency in the older population.Objective This study sought to determine whether supplementation with intramuscular vitamin D improved 25OH vitamin D levels significantly.Subjects Ninety female inpatients aged over 65 years were assigned to receive 300,000 IU of intramuscular vitamin D3 (cholecalciferol) or no intervention.Methods Baseline 25OH vitamin D and intact parathyroid hormone (iPTH) levels were taken and repeated 3 months after supplementation.Results Patients who received treatment showed a significant improvement in 25OH vitamin D levels, from 25.5 to 81 nmol/L with 11% remaining deficient. No patient became hypercalcaemic after treatment.Conclusions Vitamin D deficiency is common throughout all age groups in the Irish population and particularly the older female population who have increased risk of osteoporosis and fractures. Intramuscular vitamin D significantly improves 25OH vitamin D levels compared to no treatment and may combat non-compliance with oral medication.
0021-1265
10.1007/s11845-009-0410-9
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