Peer-Reviewed Journal Details
Mandatory Fields
Fahey, K;O'Donovan, L;Carr, M;Carty, MP;Aldabbagh, F
2010
May
European Journal Of Medicinal Chemistry
The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells
Published
WOS: 14 ()
Optional Fields
ANTITUMOR AGENTS ORGANIC-CHEMISTRY DT-DIAPHORASE MITOMYCIN-C DNA CYTOTOXICITY DESIGN RING PROLIFERATION QUINONES
45
1873
1879
Aziridinyl substituted benzimidazolequinones are more toxic than methoxy analogues towards normal human fibroblast cells (GM00637). The aziridinyl substituent is required for hypersensitive killing of Fanconi anaemia (FA) cells (PD20i) deficient in FANCD2. Despite lacking quinone functionality, 4,7-dimethoxy-N-[(aziridin-2-yl)methyl]benzimidazole also induces hypersensitivity from FA cells, similar to their response towards mitomycin C. Expression of FANCD2 (in PD20:RV) corrects FA cell hypersensitivity supporting cellular response via the FANC pathway. (C) 2010 Elsevier Masson SAS. All rights reserved.
0223-5234
10.1016/j.ejmech.2010.01.026
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