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Shologu, N;Szegezdi, E;Lowery, A;Kerin, M;Pandit, A;Zeugolis, DI
2016
September
Recreating complex pathophysiologies in vitro with extracellular matrix surrogates for anticancer therapeutics screening
Published
1
Optional Fields
EPITHELIAL-MESENCHYMAL TRANSITION ELECTROSPUN FIBROUS SCAFFOLDS CANCER STEM-CELL BREAST-CANCER TUMOR-MODEL PORE STRUCTURE COLORECTAL-CANCER XENOGRAFT MODELS ZEBRAFISH MODEL CULTURE-SYSTEMS
In vitro tumour models utilise various cancer cells and an appropriate extracellular matrix equivalent to recapitulate the in vivo tumour microenvironment. Three-dimensional tissue surrogates (e.g., decellularised tissue grafts, decellularised monolayers, hydrogels, electrospun fibres and sponges) are increasingly used as alternatives to conventional two-dimensional monolayer cultures to model the tissue environment more faithfully for drug development and screening. Herein, we critically assess the advances and shortfalls of these three-dimensional systems as in vitro models of cancer.
OXFORD
ELSEVIER SCI LTD
1359-6446
1521
1531
10.1016/j.drudis.2016.06.001
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