Peer-Reviewed Journal Details
Mandatory Fields
Ferdousi, M;Finn, DP
2018
January
Temporal Sampling And Representation Updating
Stress-induced modulation of pain: Role of the endogenous opioid system
Published
WOS: 2 ()
Optional Fields
FOOTSHOCK-INDUCED ANALGESIA ROSTRAL VENTROMEDIAL MEDULLA MESSENGER-RNA EXPRESSION COLD-WATER SWIM ENDORPHIN-LIKE IMMUNOREACTIVITY INDUCED BEHAVIORAL-RESPONSES MORPHINE-INDUCED ANALGESIA CENTRAL-NERVOUS-SYSTEM FORCED WALKING STRESS RECEPTOR GENE FAMILY
239
121
177
Depending on its nature, duration, and intensity, stress can exert potent and bidirectional modulatory effects on pain, either reducing pain (stress-induced analgesia) or exacerbating it (stress-induced hyperalgesia). The descending pain pathway has been implicated in both stress-induced analgesia and stress-induced hyperalgesia. The endogenous opioid system is widely distributed throughout the descending pain pathway and regulates nociceptive signaling, emotionality, and the response to stress. Here we review the evidence for a key role of the endogenous opioid system in stress-induced modulation of pain in rodents and humans. Understanding the neurobiological mechanisms underlying opioidergic regulation of stresspain interactions may help in identifying novel therapeutic strategies for the improved treatment of comorbid pain and stress-related disorders.
0079-6123
10.1016/bs.pbr.2018.07.002
Grant Details
Publication Themes