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Butler, RK;Finn, DP
2009
July
Stress-induced analgesia
Published
1
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NOXIOUS INHIBITORY CONTROLS ROSTRAL VENTROMEDIAL MEDULLA COLD-WATER-SWIM STIMULATION-PRODUCED ANALGESIA FOOTSHOCK-INDUCED ANALGESIA SELECTIVELY BRED MICE FEAR-CONDITIONED ANALGESIA SHOCK-INDUCED ANALGESIA AGE-RELATED DIFFERENCES HYPOTHALAMIC PARAVENTRICULAR NUCLEUS
For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, gamma-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders. (C) 2009 Elsevier Ltd. All rights reserved
OXFORD
PERGAMON-ELSEVIER SCIENCE LTD
0301-0082
184
202
10.1016/j.pneurobio.2009.04.003
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