Conference Publication Details
Mandatory Fields
Oehlmann, M;Mahon, C;Nasheuer, HP
ADVANCES IN MOLECULAR ONCOLOGY
Comparison of DNA replication in Xenopus laevis and Simian Virus 40
2007
January
Published
1
WOS: 7 ()
Optional Fields
LARGE-T-ANTIGEN ORIGIN RECOGNITION COMPLEX POLYMERASE ALPHA-PRIMASE S-PHASE CHECKPOINT MCM PROTEINS EGG EXTRACTS SACCHAROMYCES-CEREVISIAE LICENSING SYSTEM CHROMOSOME-REPLICATION HELICASE ACTIVITY
3
16
DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: origin-licensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and tagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).
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