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Reviews
Erxleben, A
2018
March
Transition metal salen complexes in bioinorganic and medicinal chemistry
Published
1
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SCHIFF-BASE COMPLEXES SUPEROXIDE DISMUTASE/CATALASE MIMETICS GALACTOSE-OXIDASE MODEL G-QUADRUPLEX DNA SYNTHETIC CATALYTIC SCAVENGER BOND-DISSOCIATION ENERGIES CYCLIC CARBONATE SYNTHESIS DOT COPPER CONJUGATE 2 XANTHENE SCAFFOLDS HYDROGEN-PEROXIDE
Salen is a common abbreviation for tetradentate N2O2 bis-Schiff base bis-phenolate ligands. Due to the ease of their synthesis, rich coordination chemistry and photophysical properties, biological and catalytic activity, salen complexes are widely employed in materials science, catalysis and biomedical science with applications ranging from enzyme models to therapeutics and biosensors to bioinspired nanotechnology. This review gives an overview of the role of metallosalens in bioinorganic and medicinal chemistry and discusses their applications as enzyme mimics, artificial enzyme cofactors, therapeutics, sensors, DNA cleavage and footprinting agents, quadruplex DNA binders and artificial DNA base pairs. (C) 2017 Elsevier B.V. All rights reserved.
LAUSANNE
ELSEVIER SCIENCE SA
0020-1693
40
57
10.1016/j.ica.2017.06.060
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