Challenging the centuries old statement cartilage do not regenerate, several reports are describing the presence of condroprogenitor populations within ostheoarthritic cartilage. Osteophytes are non-osteoplastic protrusions which are formed gradually into an OA joint into certain predictable anatomical locations. Known to be related to evolution and progress of the disease, osteophytes formation has been proposed as a in vivo stadial model for induced cartilage repair processes, remarkable little taken in account so far. The histological description of chondroprogenitors presence within an extended base of human cartilage samples, assessment of their functionality together with progress in understanding of the dysfunctional osteophytic niche are factors that could be the base of using local progenitors as a cell source for different strategies of cartilage regeneration,, especially for "in situ assisted reconstruction". The paper describes experiment set up and our preliminary results in the description and functional assessment of progenitor cells within human late stages of osteoarthritic cartilage.