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Huckins, LM;Dobbyn, A;Ruderfer, DM;Hoffman, G;Wang, WQ;Pardinas, AF;Rajagopal, VM;Als, TD;Nguyen, HT;Girdhar, K;Boocock, J;Roussos, P;Fromer, M;Kramer, R;Domenici, E;Gamazon, ER;Purcell, S;Demontis, D;Borglum, AD;Walters, JTR;O'Donovan, MC;Sullivan, P;Owen, MJ;Devlin, B;Sieberts, SK;Cox, NJ;Im, HK;Sklar, P;Stahl, EA;Johnson, JS;Shah, HR;Klein, LL;Dang, KK;Logsdon, BA;Mahajan, MC;Mangravite, LM;Toyoshiba, H;Gur, RE;Hahn, CG;Schadt, E;Lewis, DA;Haroutunian, V;Peters, MA;Lipska, BK;Buxbaum, JD;Hirai, K;Perumal, TM;Essioux, L;Rajagopal, VM;Mattheisen, M;Grove, J;Werge, T;Mortensen, PB;Pedersen, CB;Agerbo, E;Pedersen, MG;Mors, O;Nordentoft, M;Hougaard, DM;Bybjerg-Grauholm, J;Baekvad-Hansen, M;Hansen, CS;Ripke, S;Neale, BM;Corvin, A;Farh, KH;Holmans, PA;Lee, P;Bulik-Sullivan, B;Collier, DA;Huang, HL;Pers, TH;Agartz, I;Albus, M;Alexander, M;Amin, F;Bacanu, SA;Begemann, M;Belliveau, RA;Bene, J;Bergen, SE;Bevilacqua, E;Bigdeli, TB;Black, DW;Bruggeman, R;Buccola, NG;Buckner, RL;Byerley, W;Cahn, W;Cai, GQ;Campion, D;Cantor, RM;Carr, VJ;Carrera, N;Catts, SV;Chambert, KD;Chan, RCK;Chen, RYL;Chen, EYH;Cheng, W;Cheung, EFC;Chong, SA;Cloninger, CR;Cohen, D;Cohen, N;Cormican, P;Craddock, N;Crowley, JJ;Curtis, D;Davidson, M;Davis, KL;Degenhardt, F;Del Favero, J;Dikeos, D;Dinan, T;Djurovic, S;Donohoe, G;Drapeau, E;Duan, J;Dudbridge, F;Durmishi, N;Eichhammer, P;Eriksson, J;Escott-Price, V;Essioux, L;Fanous, AH;Farrell, MS;Frank, J;Franke, L;Freedman, R;Freimer, NB;Friedl, M;Friedman, JI;Fromer, M;Genovese, G;Georgieva, L;Giegling, I;Giusti-Rodriguez, P;Godard, S;Goldstein, JI;Golimbet, V;Gopal, S;Gratten, J;de Haan, L;Hammer, C;Hamshere, ML;Hansen, M;Hansen, T;Haroutunian, V;Hartmann, AM;Henskens, FA;Herms, S;Hirschhorn, JN;Hoffmann, P;Hofman, A;Hollegaard, MV;Ikeda, M;Joa, I;Julia, A;Kahn, RS;Kalaydjieva, L;Karachanak-Yankova, S;Karjalainen, J;Kavanagh, D;Keller, MC;Kennedy, JL;Khrunin, A;Kim, Y;Klovins, J;Knowles, JA;Konte, B;Kucinskas, V;Kucinskiene, ZA;Kuzelova-Ptackova, H;Kahler, AK;Laurent, C;Keong, JLC;Lee, SH;Legge, SE;Lerer, B;Li, MX;Li, T;Liang, KY;Lieberman, J;Limborska, S;Loughland, CM;Lubinski, J;Lonnqvist, J;Macek, M;Magnusson, PKE;Maher, BS;Maier, W;Mallet, J;Marsal, S;Mattingsdal, M;McCarley, RW;McDonald, C;McIntosh, AM;Meier, S;Meijer, CJ;Melegh, B;Melle, I;Mesholam-Gately, RI;Metspalu, A;Michie, PT;Milani, L;Milanova, V;Mokrab, Y;Morris, DW;Mors, O;Murphy, KC;Murray, RM;Myin-Germeys, I;Muller-Myhsok, B;Nelis, M;Nenadic, I;Nertney, DA;Nestadt, G;Nicodemus, KK;Nikitina-Zake, L;Nisenbaum, L;Nordin, A;O'Callaghan, E;O'Dushlaine, C;O'Neill, FA;Oh, SY;Olincy, A;Olsen, L;Van Os, J;Pantelis, C;Papadimitriou, GN;Papiol, S;Parkhomenko, E;Pato, MT;Paunio, T;Pejovic-Milovancevic, M;Perkins, DO;Pietilainen, O;Pimm, J;Pocklington, AJ;Powell, J;Price, A;Pulver, AE;Purcell, SM;Quested, D;Rasmussen, HB;Reichenberg, A;Reimers, MA;Richards, AL;Roffman, JL;Ruderfer, DM;Salomaa, V;Sanders, AR;Schall, U;Schubert, CR;Schulze, TG;Schwab, SG;Scolnick, EM;Scott, RJ;Seidman, LJ;Shi, JX;Sigurdsson, E;Silagadze, T;Silverman, JM;Sim, K;Slominsky, P;Smoller, JW;So, HC;Spencer, CCA;Stefansson, H;Steinberg, S;Stogmann, E;Straub, RE;Strengman, E;Strohmaier, J;Stroup, TS;Subramaniam, M;Suvisaari, J;Svrakic, DM;Szatkiewicz, JP;Soderman, E;Thirumalai, S;Toncheva, D;Tosato, S;Veijola, J;Waddington, J;Walsh, D;Wang, D;Wang, Q;Webb, BT;Weiser, M;Wildenauer, DB;Williams, NM;Williams, S;Witt, SH;Wolen, AR;Wong, EHM;Wormley, BK;Xi, HS;Zai, CC;Zheng, XB;Zimprich, F;Wray, NR;Stefansson, K;Visscher, PM;Adolfsson, R;Andreassen, OA;Blackwood, DHR;Bramon, E;Buxbaum, JD;Borglum, AD;Cichon, S;Darvasi, A;Domenici, E;Ehrenreich, H;Esko, T;Gejman, PV;Gill, M;Gurling, H;Hultman, CM;Iwata, N;Jablensky, AV;Jonsson, EG;Kendler, KS;Kirov, G;Knight, J;Lencz, T;Levinson, DF;Li, QQS;Liu, JJ;Malhotra, AK;McCarroll, SA;McQuillin, A;Moran, JL;Mortensen, PB;Mowry, BJ;Nothen, MM;Ophoff, RA;Owen, MJ;Palotie, A;Pato, CN;Petryshen, TL;Posthuma, D;Rietschel, M;Riley, BP;Rujescu, D;Sham, PC;St Clair
2019
April
Nature Genetics
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Published
Altmetric: 47WOS: 7 ()
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ACUTE INTERMITTENT PORPHYRIA COGNITIVE DEFICITS ASSOCIATION MOUSE TRANSCRIPTOME CHILDHOOD TRAITS PSYCHOSIS DISORDER VARIANTS
51
659
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.
1061-4036
10.1038/s41588-019-0364-4
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