In 2013, the University of Strathclyde became the first Scottish university to receive the prestigious THES UK entrepreneurial university of the year award. In this article, I describe how successful technology commercialization education in this leading UK-based technological university is deeply dependent on the state of the university’s entrepreneurial ecosystem. Two case studies illustrate the relatively minor “supporting” role that conventional teaching plays in the practice of technology commercialization, and the major role that a comprehensive university entrepreneurial ecosystem can play. Lessons drawn from teaching and learning technology commercialization at the University of Strathclyde are discussed. These include “teaching by stealth” through the ecosystem, basing students’ class assignments on their own technology, and the use of local role models in class. I conclude by summarizing today’s challenges and opportunities facing Strathclyde’s entrepreneurial ecosystem.