Peer-Reviewed Journal Details
Mandatory Fields
Tapeinos, C,Larranaga, A,Sarasua, JR,Pandit, A
2018
October
Nanomedicine-Nanotechnology Biology And Medicine
Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS
Published
WOS: 4 ()
Optional Fields
PLGA Collagen microspheres ROS scavengers MnO2 Apoptosis Oxidative stress HYDROGEN-PEROXIDE OXIDATIVE STRESS FREE-RADICALS NANOPARTICLES ANTIOXIDANTS CHONDROCYTES INFLAMMATION EXPRESSION HYPOXIA DISEASE
14
2397
2405
Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress. (c) 2017 Elsevier Inc. All rights reserved.
10.1016/j.nano.2017.03.022
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