Peer-Reviewed Journal Details
Mandatory Fields
Geeleher, P,Nath, A,Wang, F,Zhang, ZY,Barbeira, AN,Fessler, J,Grossman, RL,Seoighe, C,Huang, RS
Genome Biol
Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity
Optional Fields
Expression quantitative trait locus (eQTL) Genome-wide association study (GWAS) Cancer Gene regulation Deconvolution GENOME-WIDE ASSOCIATION SUSCEPTIBILITY LOCI BREAST-TUMORS GENOTYPE IMPUTATION REVEALS DECONVOLUTION SET
Expression quantitative trait loci (eQTLs) identified using tumor gene expression data could affect gene expression in cancer cells, tumor-associated normal cells, or both. Here, we have demonstrated a method to identify eQTLs affecting expression in cancer cells by modeling the statistical interaction between genotype and tumor purity. Only one third of breast cancer risk variants, identified as eQTLs from a conventional analysis, could be confidently attributed to cancer cells. The remaining variants could affect cells of the tumor microenvironment, such as immune cells and fibroblasts. Deconvolution of tumor eQTLs will help determine how inherited polymorphisms influence cancer risk, development, and treatment response.
Grant Details
Publication Themes