Peer-Reviewed Journal Details
Mandatory Fields
Balaskas, P;Goljanek-Whysall, K;Clegg, P;Fang, YX;Cremers, A;Emans, P;Welting, T;Peffers, M
2017
January
International Journal Of Genomics
MicroRNA Profiling in Cartilage Ageing
Published
Optional Fields
HUMAN ARTICULAR CHONDROCYTES TRANSCRIPTOME ANALYSIS EXPRESSION PROFILES STEM-CELLS OSTEOARTHRITIS TARGETS GENE PATHOGENESIS BIOGENESIS MECHANISMS
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.
2314-436X
10.1155/2017/2713725
Grant Details
Publication Themes