Peer-Reviewed Journal Details
Mandatory Fields
Barry, FP;Boynton, RE;Haynesworth, S;Murphy, JM;Zaia, J
1999
November
Biochemical And Biophysical Research Communications
The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105)
Published
WOS: 272 ()
Optional Fields
HUMAN BONE-MARROW BETA-BINDING-PROTEIN GROWTH-FACTOR-BETA OSTEOGENIC DIFFERENTIATION SIGNALING RECEPTORS ENDOTHELIAL-CELLS SURFACE ANTIGENS PROGENITOR CELLS IN-VITRO EXPRESSION
265
134
139
Mesenchymal stem cells are multipotent cells resident in the bone marrow throughout adulthood which have the capacity to differentiate into cartilage, bone, fat, muscle, and tendon. A number of monoclonal antibodies raised against human MSCs have been shown to react with surface antigens on these cells in vitro. A protein of molecular mass 92 kDa was immunoprecipitated using the SH-2 monoclonal antibody. This was purified and identified by peptide sequencing analysis and mass spectrometry as endoglin (CD105), the TGF-beta receptor III present on endothelial cells, syncytiotrophoblasts, macrophages, and connective tissue stromal cells. Endoglin on MSCs potentially plays a role in TGF-beta signalling in the control of chondrogenic differentiation of MSCs and also in mediating interactions between MSCs and haematopoietic cells in the bone marrow microenvironment. (C) 1999 Academic Press.
0006-291X
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