Peer-Reviewed Journal Details
Mandatory Fields
Curtin, CM;Cunniffe, GM;Lyons, FG;Bessho, K;Dickson, GR;Duffy, GP;O'Brien, FJ
2012
February
Advanced Materials (Deerfield Beach, Fla.)
Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation
Published
Altmetric: 1WOS: 98 ()
Optional Fields
MORPHOGENETIC PROTEIN-2 GAG SCAFFOLDS ADENOVIRAL VECTOR THERAPY MODEL DNA
24
749
The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.
0935-9648
10.1002/adma.201103828
Grant Details
Publication Themes