Peer-Reviewed Journal Details
Mandatory Fields
Huang, J;Hastings, CL;Duffy, GP;Kelly, HM;Raeburn, J;Adams, DJ;Heise, A
2013
January
Biomacromolecules
Supramolecular Hydrogels with Reverse Thermal Gelation Properties from (Oligo)tyrosine Containing Block Copolymers
Published
Altmetric: 4WOS: 52 ()
Optional Fields
PHENOLIC HYDROXYL IONIZATION BIOMEDICAL APPLICATIONS POLYPEPTIDE HYDROGELS PEPTIDE AMPHIPHILES PROTEINS COPOLYPEPTIDES MOLECULES BIODEGRADATION POLYMERIZATION DITYROSINE
14
200
206
Novel block copolymers comprising poly(ethylene glycol) (PEG) and an oligo(tyrosine) block were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr(6) undergoes thermoresponsive hydrogelation at a low concentration range of 0.25-3.0 wt % within a temperature range of 25-50 degrees C. Cryogenic transmission electron microscopy (Cryo-TEM) revealed a continuous network of fibers throughout the hydrogel sample, even at concentrations as low as 0.25 wt %. Circular dichroism (CD) results suggest that better packing of the beta-sheet tyrosine block at increasing temperature induces the reverse thermogelation. A preliminary assessment of the potential of the hydrogel for in vitro application confirmed the hydrogel is not cytotoxic, is biodegradable, and produced a sustained release of a small-molecule drug.
1525-7797
10.1021/bm301629f
Grant Details
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