Peer-Reviewed Journal Details
Mandatory Fields
Ryan, AJ;O'Neill, HS;Duffy, GP;O'Brien, FJ
2017
October
Current Opinion In Pharmacology
Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation
Published
Altmetric: 11WOS: 3 ()
Optional Fields
SUBCUTANEOUS IMPLANTS DIFFUSION-CHAMBERS NONHUMAN-PRIMATES PANCREATIC-ISLETS BETA-CELLS TRANSPLANTATION BIOMATERIAL THERAPY RODENTS SAFETY
36
66
71
Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.
1471-4892
10.1016/j.coph.2017.07.013
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