Peer-Reviewed Journal Details
Mandatory Fields
de Oliveira, FCS;Olvera, D;Sawkins, MJ;Cryan, SA;Kimmins, SD;da Silva, TE;Kelly, DJ;Duffy, GP;Kearney, C;Heise, A
2017
December
Biomacromolecules
Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling
Published
Altmetric: 14WOS: 3 ()
Optional Fields
RING-OPENING POLYMERIZATION POLY-EPSILON-CAPROLACTONE HIGH-MOLECULAR-WEIGHT OMEGA-PENTADECALACTONE NANOFIBROUS SCAFFOLDS MECHANICAL-PROPERTIES REGENERATIVE MEDICINE MACROLACTONES DELIVERY COPOLYMERS
18
4292
4298
Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PG1) into well-defined fibers with an average diameter of 9 mu m is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology. Seeding mesenchymal stem cells (MSCs) onto both cross-linked and non-cross-linked PG1 fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load cross-linked PG1 with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering.
1525-7797
10.1021/acs.biomac.7b01335
Grant Details
Publication Themes