Peer-Reviewed Journal Details
Mandatory Fields
Philip, RCM;Dauvermann, MR;Whalley, HC;Baynham, K;Lawrie, SM;Stanfield, AC
2012
February
Neuroscience And Biobehavioral Reviews
A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders
Published
Altmetric: 5WOS: 115 ()
Optional Fields
HIGH-FUNCTIONING AUTISM PERVASIVE DEVELOPMENTAL DISORDERS MEDIAL PREFRONTAL CORTEX FIGURES TASK-PERFORMANCE MAGNETIC-RESONANCE ASPERGER-SYNDROME NEURAL BASIS EFFECTIVE CONNECTIVITY EXECUTIVE FUNCTION FACE RECOGNITION
36
901
942
Recent years have seen a rapid increase in the investigation of autism spectrum disorders (ASD) through the use of functional magnetic resonance imaging (fMRI). We carried out a systematic review and ALE meta-analysis of fMRI studies of ASD. A disturbance to the function of social brain regions is among the most well replicated finding. Differences in social brain activation may relate to a lack of preference for social stimuli as opposed to a primary dysfunction of these regions. Increasing evidence points towards a lack of effective integration of distributed functional brain regions and disruptions in the subtle modulation of brain function in relation to changing task demands in ASD. Limitations of the literature to date include the use of small sample sizes and the restriction of investigation to primarily high functioning males with autism. (c) 2011 Elsevier Ltd. All rights reserved.
0149-7634
10.1016/j.neubiorev.2011.10.008
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