Peer-Reviewed Journal Details
Mandatory Fields
Hinney, A;Scherag, A;Jarick, I;Albayrak, O;Putter, C;Pechlivanis, S;Dauvermann, MR;Beck, S;Weber, H;Scherag, S;Nguyen, TT;Volckmar, AL;Knoll, N;Faraone, SV;Neale, BM;Franke, B;Cichon, S;Hoffmann, P;Nothen, MM;Schreiber, S;Jockel, KH;Wichmann, HE;Freitag, C;Lempp, T;Meyer, J;Gilsbach, S;Herpertz-Dahlmann, B;Sinzig, J;Lehmkuhl, G;Renner, TJ;Warnke, A;Romanos, M;Lesch, KP;Reif, A;Schimmelmann, BG;Hebebrand, J
2011
December
American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder
Published
Altmetric: 3WOS: 51 ()
Optional Fields
DEFICIT HYPERACTIVITY DISORDER RESTLESS-LEGS-SYNDROME MOLECULAR-GENETICS BIPOLAR DISORDER COMMON VARIANTS ADHD LINKAGE GENES METAANALYSIS LOCI
156B
888
897
The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 x 10(-7)) have potential relevance for ADHD (e. g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values <= 7.57 x 10(-5)) were chosen for confirmation. Genotyping of these SNPs in up to 320 independent German families comprising at least one child with ADHD revealed directionally consistent effect-size point estimates for 19 (10 not consistent) of the SNPs. In silico analyses of the 30 SNPs in the largest meta-analysis so far (2,064 trios, 896 cases, and 2,455 controls) revealed directionally consistent effect-size point estimates for 16 SNPs (11 not consistent). None of the combined analyses revealed a genome-wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P-values compared to SNPs within random sets of genes of the same size. We did not find genome-wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD. (C) 2011 Wiley Periodicals, Inc.
1552-4841
10.1002/ajmg.b.31246
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