Peer-Reviewed Journal Details
Mandatory Fields
Breathnach, A,Concannon, E,Dorairaj, JJ,Shaharan, S,McGrath, J,Jose, J,Kelly, JL,Leahy, MJ
2018
January
Journal Of Medical Imaging
Preoperative measurement of cutaneous melanoma and nevi thickness with photoacoustic imaging
Published
WOS: 2 ()
Optional Fields
biopsy Breslow depth spectral unmixing histology staging IN-VIVO MALIGNANT-MELANOMA SKIN-LESIONS TOMOGRAPHY BIOPSY MICROSCOPY MANAGEMENT ULTRASOUND DIAGNOSIS
5
Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented cutaneous lesions suspicious for melanoma to test the feasibility of a handheld linear-array photoacoustic probe in imaging lesion architecture and measuring tumor depth. The probe was assessed in terms of measurement accuracy, image quality, and ease of application. Photoacoustic scans included single wavelength, spectral unmixing, and three-dimensional (3-D) scans. The photoacoustically measured lesion thickness gave a high correlation with the histological thickness measured from resected surgical samples (r = 0.99, P < 0.001 for melanomas, r = 0.98, P < 0.001 for nevi). Thickness measurements were possible for 23 of 26 cases for nevi and all (6) cases for melanoma. Our results show that handheld, lineararray PAI is highly reliable in measuring cutaneous lesion thickness in vivo, and can potentially be used to inform biopsy procedure and improve patient management. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
10.1117/1.JMI.5.1.015004
Grant Details
Publication Themes