Peer-Reviewed Journal Details
Mandatory Fields
Dai Z, Kawde AN, Xiang Y, La Belle JT, Gerlach J, Bhavanandan VP, Joshi L, Wang J
2006
August
Journal Of The American Chemical Society
Nanoparticle-based sensing of glycan-lectin interactions.
Published
()
Optional Fields
128
31
10018
10019
Here we present the first report on nanoparticle-based biosensing of glycan markers of diseases. The protocol relies on the competition between a nanocrystal (CdS)-tagged sugar and the target sugar for the binding sites of surface-confined lectin and monitoring the extent of competition through highly sensitive electrochemical detection of the captured nanocrystal. This development is expected to allow decentralized detection of carbohydrate moieties and lectin-carbohydrate interactions to be performed more rapidly, sensitively, inexpensively, and reliably.
10.1021/ja063565p
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