Conference Publication Details
Mandatory Fields
Cinelli, I,Destrade, M,Duffy, M,McHugh, P,
Electro-Mechanical Response of a 3D Nerve Bundle Model to Mechanical Loads Leading to Axonal Injury
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
2017
January
Published
1
()
Optional Fields
TRAUMATIC BRAIN-INJURY SQUID GIANT-AXON STRAIN COMPRESSION MAGNITUDE SYSTEM DAMAGE
978
981
Axonal damage is one of the most common pathological features of traumatic brain injury, leading to abnormalities in signal propagation for nervous systems. We present a 3D fully coupled electro-mechanical model of a nerve bundle, made with the finite element software Abaqus 6.13-3. The model includes a real-time coupling, modulated threshold for spiking activation and independent alteration of the electrical properties for each 3-layer fibre within the bundle. Compression and tension are simulated to induce damage at the nerve membrane. Changes in strain, stress distribution and neural activity are investigated for myelinated and unmyelinated nerve fibres, by considering the cases of an intact and of a traumatized nerve membrane. Results show greater changes in transmitting action potential in the myelinated fibre.
Grant Details
Publication Themes