Peer-Reviewed Journal Details
Mandatory Fields
O'Duill, M;Dubost, E;Pfeifer, L;Gouverneur, V
2015
July
Organic Letters
Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silanes with Aryl Halides
Published
Altmetric: 1WOS: 8 ()
Optional Fields
COPPER-CATALYZED TRIFLUOROMETHYLATION MESOGENIC CORE STRUCTURE X-RAY-DIFFRACTION LIQUID-CRYSTALS IODIDES FLUORINATION ARENES PERFLUOROALKYLATION COMPLEXES BROMIDES
17
3466
3469
The synthesis of arylCF(2)CF(2)SiMe(3) and their reactivity in cross-coupling reactions with aryl iodides and aryl bromides to afford a range of 1,1,2,2-tetrafluoro-1,2-aryl-ethanes is reported. The use of pyridine as an alternative to phenanthroline, and the ability to carry out the reaction at 60 degrees C or room temperature are the key features of this Cu-Ag mediated cross-coupling methodology. The chemistry is compatible with (hetero)aryl halides, offering a platform to develop products of interest in material and medicinal chemistry.
1523-7060
10.1021/acs.orglett.5b01510
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